A Potential Target for Modulation of Vascular Reactive Oxygen Species in Atherosclerotic Arteries
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Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries.
BACKGROUND Despite a concerted effort by many laboratories, the critical subunits that participate in vascular smooth muscle cell (VSMC) NADPH oxidase function have yet to be elucidated. Given the potential therapeutic importance of cell-specific inhibition of NADPH oxidase, we investigated the role of Nox activator 1 (NoxA1), a homolog of p67phox, in VSMC NADPH oxidase function and atheroscler...
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A major complication of type 2 diabetes (T2D) is atherosclerotic vascular disease, which develops earlier and more rapidly in patients with T2D than in subjects without diabetes (1). One of the characteristic features of T2D is excessive generation of reactive oxygen species (ROS) in the artery wall and the resultant oxidative stress, which contributes to the development of endothelial dysfunct...
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تاریخ انتشار 2010